iVenomDB

Basic info

Organism	Apis mellifera
Taxonomy	Insecta > Hymenoptera > Apidae > Apis > Apis mellifera
Protein Description	Venom dipeptidyl peptidase 4
Mass Weight	87935.74 Da
Isoelectric Point	5.72
Expression	Highly expressed in venom gland

Annotation

Function

Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N- termini provided that the penultimate residue is proline. May process promelittin into its active form and/or modulate the chemotactic activity of immune cells after the insect sting.

Pfam

PF00930

DPPIV_N

Features

Feature key	Position	Length
Signal Peptide	1..23	23
Chain	24..775	752

Cross-Reference

NCBI Nucleotide	EU564832.1
NCBI Protein	ACB70230.1
UniProt	B2D0J4

Sequence

CDS[Download]

ATGGAGGTACTGGTGCAGCTGGCGCTGCTGCTGGTGGTGCACGGATCGCTGGTCGTCCTCGTTGCTGGAAAATCCGTTCCACGAGTGATCGACCAGGACTTGGAGAGATACGAGCCCCTCGAAGAGGAGGATCATCGGGGTGCAAGGGTCCCTTTCAACCTGGAGGAGACTTACGATCAAAGTTTCCGGGCGAACAGTTTCAACGGCACCTGGAAAACGGACAGGGAAATCCTTTACTCGGACAACTACGTCGGCGATATCCGATTGTTCGACGTCACGACAGGATCGGGCACCGTTCTCCTCGATTCGTCCGTCACGGCCGATTTCGACAAAGCGTCCGTGATGTTTTCCTTCGACAATTCCCACGTAGCTATCGGCCACGACTACGTGAACGGGTTTCGATACTCGATACACCAAAAGTGCACCGTGTACAACATTAAATCCAGAACGTTCACGGATATCGCGAATGGCGATCGCATACCACTGTTCAAATGGTCGCCCACGAGGAACGCTTTGATTTACGTTCACAAGAACGATATCTATTATCAGGTGTTCTTCGAGGGTGGCAGCGACACTCGAAGGATAACGAACACCGGCGTCCCGGACATCGTTTTCAACGGGATACCCGACTGGGTTTACGAGGAGGAAGTGCTGGGCTCCCCGGTCGCATTCTGGATCTCGCCCGACGGACGACACCTTGCTTTCGCCACGTTCAACGACACCAACGTCCGCGATATCGTGATATCTAAATACGGCTCCCCTGGAAACTCGAGGGATCAATATCCGAACGAGATCAGGATAAAATATCCGAAAGCGGGCACCACGAACCCATTCGTGTCCCTGAGCGTGATCGACTTGCACGATCCCTCCTCGAAATTGATCGATCTTCCGCCGCCTGTCGATGTCGTTGGAGCAGACAACGTTCTTTATACCGCGAACTGGAGGAGGGACGGCGAGATTGTTGCGACGTGGACGAACAGGGTGCAGAACAAGGCCCAATTAGTGCTGTACGACACGAAGGGTAACGCGAATAATATTTATTACGAGGAGGAGACCGAGGGTTGGCTTCGCATCCAACCACCCCTCTATCACGACCGATACGTGATCGTTGCGAAGCTTCAAGACTCGGGCACGAAGGCGGGACGGTTTCTCCACGCGACGAGGCTCGAGTACAGGAACGGCGCCCTGGTCGACGAGACGGATTTGACGCCTGGAACGTGCGAGGTTATCTCCCTGTTGCTCGTCGACCACGCCAGGGCCAGGCTCTATTACTTGGGCACCGAGCTCGGCAAACCATCCCACAAGAATCTCTACTCCGTCCAATTGAGCGGCAACGAGCCGCCCGTTTGCCTGTCGTGCGACGTCCTCACCCCCGAGGGGAATCGTTGCACCTACGCCTACGCCTACTTCTCGACCAACGGTTCTCATTACGCGTTGTACTGCGCCGGCCCAGACCCTGTCTTCATCGCGATAGTGAACGCGAATCACAGGCAGATCTCGATTTGGGAGGAGAACCGATCCCTTAGACGCAAGTTGGCCGCCCGTACTCAGCCGATTGTCAAGAATTTCAACGTGAACGCGAACGGGTACACGAACAAGGTTAAGCTTTACCTGCCGCCCGACTTCGACGAGACGAAAAAGTATCCTCTGCTGATCACCGTGTACGCAGGGCCGAACACTATCAGGATTACGGAGGAGGCTACGTACGGGTTCGAGTCGTACATAGTGACGAACAGGAGCGTAATTTATGGGCGCATCGACGGGCGTGGATCGGCGTACAAAGGGAGCAAGATGCTGTTCGAGATCTATCGCCGACTCGGCACCGTGGAGATCGAGGATCAGATTATTATCACCAGAACGCTGCAGGAGAAGTACTCGTGGATCGATTCGAACAGGACGGGCATATGGGGTTGGAGTTACGGCGGTTTCTCGGCCGCCATGGTGCTGGCCACCGACGCCGAGTCGGTGTTCAAGTGCGGCATATCAGTCGCACCCGTCACCTCCTGGATTTATTACGATTCCTTGTACACGGAACGGTTCATGGGCCTGCCGACCCCGGAGGACAATCAGAGCGGTTACAACGACACGGACGTGAGCAGGAGGGTGGAGGGTATGCGAGGGAAAAAGTACATGCTGATACACGGGACAGCGGACGACAACGTGCACTACCAGCAAACCATGATGCTGAACAAGGCTTTGGTGAACAGCGACATAATGTTCCAGCAGCAGACGTACACGGACGAGGCGCACGCCCTCGGGAACGTCTTCCCCCATCTCTACCACACCACGGACCGATTCTGGGCCAATTGTCTGGGATACTCCCACTGA

Protein[Download]

MEVLVQLALLLVVHGSLVVLVAGKSVPRVIDQDLERYEPLEEEDHRGARVPFNLEETYDQSFRANSFNGTWKTDREILYSDNYVGDIRLFDVTTGSGTVLLDSSVTADFDKASVMFSFDNSHVAIGHDYVNGFRYSIHQKCTVYNIKSRTFTDIANGDRIPLFKWSPTRNALIYVHKNDIYYQVFFEGGSDTRRITNTGVPDIVFNGIPDWVYEEEVLGSPVAFWISPDGRHLAFATFNDTNVRDIVISKYGSPGNSRDQYPNEIRIKYPKAGTTNPFVSLSVIDLHDPSSKLIDLPPPVDVVGADNVLYTANWRRDGEIVATWTNRVQNKAQLVLYDTKGNANNIYYEEETEGWLRIQPPLYHDRYVIVAKLQDSGTKAGRFLHATRLEYRNGALVDETDLTPGTCEVISLLLVDHARARLYYLGTELGKPSHKNLYSVQLSGNEPPVCLSCDVLTPEGNRCTYAYAYFSTNGSHYALYCAGPDPVFIAIVNANHRQISIWEENRSLRRKLAARTQPIVKNFNVNANGYTNKVKLYLPPDFDETKKYPLLITVYAGPNTIRITEEATYGFESYIVTNRSVIYGRIDGRGSAYKGSKMLFEIYRRLGTVEIEDQIIITRTLQEKYSWIDSNRTGIWGWSYGGFSAAMVLATDAESVFKCGISVAPVTSWIYYDSLYTERFMGLPTPEDNQSGYNDTDVSRRVEGMRGKKYMLIHGTADDNVHYQQTMMLNKALVNSDIMFQQQTYTDEAHALGNVFPHLYHTTDRFWANCLGYSH

3D Structure

Alphafold Prediction

Publication

1.	Blank S., Seismann H., Bockisch B., Braren I., Cifuentes L., McIntyre M., Ruhl D., Ring J., Bredehorst R., Ollert M.W., Grunwald T., Spillner E.; "Identification, recombinant expression, and characterization of the 100 kDa high molecular weight hymenoptera venom allergens Api m 5 and Ves v 3."; J. Immunol. 184:5403-5413(2010).
2.	"Insights into social insects from the genome of the honeybee Apis mellifera."; Nature 443:931-949(2006).

Venom Protein Card