Venom Protein Card
Accession: Pre00072 Venom serine protease Bi-VSP [Bombus ignitus]
Basic info
| Organism | Bombus ignitus |
| Taxonomy | Insecta > Hymenoptera > Apidae > Bombus > Bombus ignitus |
| Protein Description | Venom serine protease Bi-VSP |
| Mass Weight | 39460.81 Da |
| Isoelectric Point | 6.26 |
| Expression | Highly expressed in venom gland |
Annotation
| Function | Multifunctional venom serine protease. In insects, it acts as an arthropod prophenoloxidase-activating factor, thereby triggering the phenoloxidase cascade. When injected into larvae, it induces a lethal melanization response in target insects by modulating the innate immune response. In mammals, it converts fibrinogen into fibrin, activates prothrombin, and also degrades fibrin. In mammal, it may act in a cooperative manner with the serine protease inhibitor Bi-KTI (AC G3LH89) to promote the spread of bee venom under anti-bleeding conditions. | ||
| Pfam |
|
Features
| Feature key | Position | Length |
| Signal Peptide | 1..26 | 26 |
| Propeptide | 27..113 | 87 |
| Chain | 114..360 | 247 |
Sequence
Publication
| 1. |
Choo Y.M., Lee K.S., Yoon H.J., Kim B.Y., Sohn M.R., Roh J.Y., Je Y.H., Kim N.J., Kim I., Woo S.D., Sohn H.D., Jin B.R.; "Dual function of a bee venom serine protease: prophenoloxidase-activating factor in arthropods and fibrin(ogen)olytic enzyme in mammals."; PLoS ONE 5:E10393-E10393(2010). |
| 2. |
Choo Y.M., Lee K.S., Yoon H.J., Qiu Y., Wan H., Sohn M.R., Sohn H.D., Jin B.R.; "Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitor."; PLoS ONE 7:E32269-E32269(2012). |