Venom Protein Card
Accession: Pre00110 Phospholipases A2 [Bracon nigricans]
Basic info
| Organism | Bracon nigricans |
| Taxonomy | Insecta > Hymenoptera > Braconidae > Habrobracon > Bracon nigricans |
| Protein Description | Phospholipases A2 |
| Mass Weight | 18965.57 Da |
| Isoelectric Point | 7.12 |
| Expression | Highly expressed in venom gland |
Annotation
| Function | PLA2s (EC 3.1.1.4) are a large super-family of lipolytic enzymes that cleave the glycerol backbone of phospholipids, usually in a metal-dependent reaction, to release free fatty acids and lysophospholipids. These products of lipid hydrolysis (i.e., arachidonic and linoleic acid) are cytotoxic, as demonstrated by many studies on catalytically active venom PLA2s exerting neurotoxic [68, 69], myotoxic, anticoagulant and antibacterial activities. A pharmacological effect independent of catalytic activity is also predicted for divergent putative homologs of BnPLA2 in other Hymenoptera | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1..21 | 21 |
| Chain | 22..167 | 146 |
Cross-Reference
Sequence
Publication
| 1. |
Becchimanzi A, Avolio M, Bostan H, Colantuono C, Cozzolino F, Mancini D, Chiusano ML, Pucci P, Caccia S, Pennacchio F.; Venomics of the ectoparasitoid wasp Bracon nigricans.; BMC Genomics 2020 Jan 10;21(1):34. |