Venom Protein Card
Accession: Pre00541 M-poneratoxin-Dq3c [Dinoponera quadriceps]
Basic info
| Organism | Dinoponera quadriceps |
| Taxonomy | Insecta > Hymenoptera > Formicidae > Dinoponera > Dinoponera quadriceps |
| Protein Description | M-poneratoxin-Dq3c |
| Mass Weight | 7079.28 Da |
| Isoelectric Point | 4.89 |
| Expression | Highly expressed in venom gland |
Annotation
| Function | May have antimicrobial properties, like most ant linear peptides (Probable). In addition, when tested in vitro on the parasite Trypanosoma cruzi (responsible of the Chagas disease), is able to potently reduce the number of the three forms (epimastigote, trypomastigote and amastigote) by inducing cell death through necrosis. | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1..23 | 23 |
| Propeptide | 24..43 | 20 |
| Peptide | 44..66 | 23 |
| Peptide | 44..56 | 13 |
| Peptide | 44..54 | 11 |
Sequence
Publication
| 1. |
Torres A.F., Huang C., Chong C.M., Leung S.W., Prieto-da-Silva A.R., Havt A., Quinet Y.P., Martins A.M., Lee S.M., Radis-Baptista G.; "Transcriptome analysis in venom gland of the predatory giant ant Dinoponera quadriceps: insights into the polypeptide toxin arsenal of hymenopterans."; PLoS ONE 9:E87556-E87556(2014). |
| 2. |
Lima D.B., Mello C.P., Bandeira I.C.J., Pessoa Bezerra de Menezes R.R.P., Sampaio T.L., Falcao C.B., Morlighem J.R.L., Radis-Baptista G., Martins A.M.C.; "The dinoponeratoxin peptides from the giant ant Dinoponera quadriceps display in vitro antitrypanosomal activity."; Biol. Chem. 399:187-196(2018). |
| 3. |
Robinson S.D., Mueller A., Clayton D., Starobova H., Hamilton B.R., Payne R.J., Vetter I., King G.F., Undheim E.A.B.; "A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family."; Sci. Adv. 4:EAAU4640-EAAU4640(2018). |