iVenomDB

Basic info

Organism	Vespula vulgaris
Taxonomy	Insecta > Hymenoptera > Vespidae > Vespula > Vespula vulgaris
Protein Description	Venom dipeptidyl peptidase 4 precursor
Mass Weight	88922.76 Da
Isoelectric Point	6.15
Expression	Highly expressed in venom gland

Annotation

Function

Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N- termini provided that the penultimate residue is proline. May process venom proteins into their active forms and/or modulate the chemotactic activity of immune cells after the insect sting.

Pfam

PF00930

DPPIV_N

Features

Feature key	Position	Length
Signal Peptide	1..25	25
Chain	26..776	751

Cross-Reference

NCBI Nucleotide	EU420987.1
NCBI Protein	ACA00159.1
UniProt	B1A4F7

Sequence

CDS[Download]

ATGGTTCCACTACGAAGTTTCGTACTTCTTAACAGCCTCTTCCTTGTCTTATTGGCAGCGCGAACAGTAGTGACTCGTGTTATCGACAAGGACAACTCGGACAGGATAGTCAAGACTCAGAATGATCAGAATCTTTCCAAAGTACCCTTCAACCTTGAAGAAACCTACACTGCCGATTTTCTAGCGTACGTCTTCAACGGCACTTGGACATCGGACACCACGATAGTTTATACGGATAGAAGGACCGGAGATATTCTTCAGTTCGACGTTATCAAGCAACGATCGACTCTGATCGTCGATTCATCGGTTATGGATGCTTACATAGTTTCGAATTATGTATTATCGCCGAAAGGACGATATCTTTTGATCGGATACGATCTTAAAAAAGGATACCGATATTCGACATTCATGAGATACGTCATTTATGATATTGAACATAGAGCATATCATAAAATTGGTAATGACATGCATATAGCGCTTGCCAAATGGGCACCATTAACAGACGATTTAATATATATTCTCGACAACGATATTTACTACATGCGTTTCTCTAACAACGGTTTTAATGATGTTCAAAGAGTGACGTATGATGGTATTAGCGGAATCGTTTACAATGGCGTGCCTGATTGGGTTTATGAAGAGGAAGTGTTGCAGGATTCATCGGCAATATGGTTTTCACCGGATGGAAATCACCTAGCTTATGCGTCTTTCGATGACAGAAATGTCCAGGAAATCTTGTACCTTCATTATGGAGAACCCGGCAACCTCGATGACCAATATCCCACGGAAGTGAAGATTAAGTACCCCAAGGTTGGCACTCTGAATCCTGTGGTATCTTTGACGCTCGTCGATCTTCACGATCCAACGTTAAATAAGATCGATTTGAAGGCCCCCCATTACGCAGTTGGCACAGACAATTTGCTGTACAATGTTCAATGGAAAGATTTCGATCATGTGGTTGTTACGTGGTCGAATCGCGTACAAAACAAAACTGAAATAGTTTGGTACAATATGTACGGTGAAATTGTTAAGACGTTGCACGTCGTTGAACACAAGGGATGGTTGGATATTAAACATCTATTCTTCTACAAAGGTTCCGTTTACATACGGAAGTTACAACCGTCTGGTACCAAGGCTGGAAGATTTCATCACGTGACGAGATACGACGAAACTTTCAAACAATCACCGACTCAAATGGATTTAACTCCAGATGCTATAGAGGTTCAAAATATTTGTACAATCGACCAATCCAATGGCAGAATTTACTATTTAGCCAGTGGACTCGGGAAACCGTCCCAAAAAAATTTATATTCTGTGCCTGCCGATGGTAGCGAGAAACCTACTTGCATATCTTGCAACGTCCTGACGCCGGAAGGTAACGTCTGTACATACGCAGATGCGATCTTCTCGCCACTTGGACAGTATTACGTGTTAGTCTGTCATGGTCCTGATCCAGCTTTCGTTAGTATTTTTAATAATGCTCACCAAAAAGTTTATTCGTGGGAAAACAATCTGTCTTTACGAAAGAAACTTGCAAAGCGACACTTACCTCTCGTCAAAGACTTGGACGTTCGAGCGAACGGATACGAGAGCAAAGTCAGACTCTTTTTACCGCACAACTTCGACGAAAGTAAATCGTATCCGATGTTGGTCAATGTATACGCTGGACCAAATACGTTGAAAATAATCGACGCAGCTTCATACGGTCATCAAGTGTACATGACAACGAATCGTAGCGTGATCTATGCTTATATAGATGGTCGAGGATCATCGAATAAGGGTAGCAAAATGCTTTTCTCGATTTATAGAAAATTAGGTACCGTTGAGGTTGAGGATCAGATCACTGTAACCAGACAACTTCAAGAAATGTTTCCTTGGATCGATTCTAAGAGAACGGGAGTCTGGGGATGGAGTTACGGTGGCTTTTCCACCGCTATGATTTTGGCAAAGGATACATCTTTTGTTTTCAAGTGCGGTATAGCCATAGCACCAGTATCCTCTTGGATTTATTATGATTCGATTTATACTGAAAGATTTATGGGTTTTCCAACACCAGAGGACAATCTTAGTGGTTACAATGAAACGGACGTGTCAAGACGAGTGGAAGATATTCGAGGGAAGAAGTTTATGTTGATACATGGTAGCGGTGATGATAACGTTCATTATCAACAATCATTGGCATTGGCAAAGGCCCTAGAGAAAGCCGATGTAATGTTCGAACAGATTACTTACACGGACGAAGCACATGCGCTCTTTGGTGTCTTGCCTCACCTTTATCATACGATGGATAGATTTTGGAGCGATTGTTTCAGTCTGTCTCACGCTCACTGA

Protein[Download]

MVPLRSFVLLNSLFLVLLAARTVVTRVIDKDNSDRIVKTQNDQNLSKVPFNLEETYTADFLAYVFNGTWTSDTTIVYTDRRTGDILQFDVIKQRSTLIVDSSVMDAYIVSNYVLSPKGRYLLIGYDLKKGYRYSTFMRYVIYDIEHRAYHKIGNDMHIALAKWAPLTDDLIYILDNDIYYMRFSNNGFNDVQRVTYDGISGIVYNGVPDWVYEEEVLQDSSAIWFSPDGNHLAYASFDDRNVQEILYLHYGEPGNLDDQYPTEVKIKYPKVGTLNPVVSLTLVDLHDPTLNKIDLKAPHYAVGTDNLLYNVQWKDFDHVVVTWSNRVQNKTEIVWYNMYGEIVKTLHVVEHKGWLDIKHLFFYKGSVYIRKLQPSGTKAGRFHHVTRYDETFKQSPTQMDLTPDAIEVQNICTIDQSNGRIYYLASGLGKPSQKNLYSVPADGSEKPTCISCNVLTPEGNVCTYADAIFSPLGQYYVLVCHGPDPAFVSIFNNAHQKVYSWENNLSLRKKLAKRHLPLVKDLDVRANGYESKVRLFLPHNFDESKSYPMLVNVYAGPNTLKIIDAASYGHQVYMTTNRSVIYAYIDGRGSSNKGSKMLFSIYRKLGTVEVEDQITVTRQLQEMFPWIDSKRTGVWGWSYGGFSTAMILAKDTSFVFKCGIAIAPVSSWIYYDSIYTERFMGFPTPEDNLSGYNETDVSRRVEDIRGKKFMLIHGSGDDNVHYQQSLALAKALEKADVMFEQITYTDEAHALFGVLPHLYHTMDRFWSDCFSLSHAH

3D Structure

Alphafold Prediction

Publication

1.

Blank S., Seismann H., Bockisch B., Braren I., Cifuentes L., McIntyre M., Ruhl D., Ring J., Bredehorst R., Ollert M.W., Grunwald T., Spillner E.;
"Identification, recombinant expression, and characterization of the 100 kDa high molecular weight hymenoptera venom allergens Api m 5 and Ves v 3.";
J. Immunol. 184:5403-5413(2010).

Venom Protein Card