iVenomDB

Basic info

Organism	Vespula vulgaris
Taxonomy	Insecta > Hymenoptera > Vespidae > Vespula > Vespula vulgaris
Protein Description	Vitellogenin
Mass Weight	199686.96 Da
Isoelectric Point	6.72
Expression	Highly expressed in venom gland

Annotation

Function

This finding renders the vitellogenins important allergens. Moreover the newly identified vitellogenins represent a novel pair of cross-reactive pan-allergens in the venoms of A. mellifera and V. vulgaris

Pfam

PF01347

Vitellogenin_N

Features

Feature key	Position	Length
Signal Peptide	1..17	17
Chain	18..1756	1739

Cross-Reference

NCBI Nucleotide	JN794080.1
NCBI Protein	AER70365.1
UniProt	G8IIT0

Sequence

CDS[Download]

ATGCGGTCTCGTTTTATTCTGCTACTCCTTGGAGTTGCCGTGAGTAATCTCGATAACAACATCGAGCATGGCTGGAAAGTTGGGGAAGAATATCAATATCTCGTACGTAGTCGTACCCTCACTGGACTACAGACATTATCTGATCAATACGCTGGTATTCTAATGAAAGCGACGCTAAGGATTCAATGTAACTCGCCCGACACTCTTAGAGCACAATTATTGAAGCCGCAGTATGCTCAGATACACAAGAAACTACCGGACGGTTGGGATTCTCGTATCTCTGATCAGATGTTAGAACACAAGCATCTACCGCTTTCTAACGAACCCTTCGTGATCAAATTGAAACATGGAGTCATAAGAGACTTGATCGTCAGCAAAAATGTACCAACTTGGGAAGTCAATATCATCAAAAGTATCATCAGTCAGTTCCAAGCTGATACGCAAGGAGAAAATTTGAAGGGAAATAAGAATACTCAAATCCCTGAAGATGATAATCCCTTCGCGACGTTCCGTGTCATGGAAGACTGCGTAAGTGGAAAATGTGAGGTCCTCTACGACGTTGTACCATTAACGGAGGACGTTCTCCAACATCGTCCACACATATTGCCAAAACCAGAATTACGTGGCAACGGAGAACACATTTACATAACGAAAACAAGGAACTACGACAAGTGCGAACAACGTATGGACTATTATTTTGGAATAAGTGGAAATGCAAACTGGGAATCCGATATTAGGAACAATGATAAAATCATGAAGAAATCATCAACAAGTAACATGGTTATATCTGGAAACCTCAAGAACTTTGTCATACAAACGGCAGTAACGACAACTGAAATAATCATGAAGCCCAGACTTGTAGATGACCAAGAGAGCATCGTAATAAGTAAAATGAATGTGACTCTCGTTAGCGTCAATAAAGTTTCGAGCCCGATACCAGCACCGAATAATCCTGAATCAACTGGAAATCTGGTTTACACTTACAACGATCCATTCTCAAAAACAGTACAGAGACGACTTGGACGACCTAGCGTAAGTCCCAATTCAATGTCCAATGAACTGGATTCTTCTGCCGATTCTGACGAAGACCTACGACTCATGAGGGAGAAATACGGCAAAAGCGATAAGATGAACGTTGTTAGCGACGAGGATAAAGCATTCCGGCAGATGAAGCCAACGTTACACGAAGCACCTAAAAATCCTATGCTACCATTATTCATAGGTAACAATGGCAAGGCGGTCGTGATGTCTGATAAGATCAATTCTGGTAAAATGGTAATGACGCTTGTCCAAGAAATTGCGAGCGAAATGGAAGATCCAAACGTTATGCCTGATCGAGAAACCCTAGAAAAATTCACGATTGTTTCTAGATTGATCAGTAGTATGAGTCTAGAACAGATCAATAAGGCCGAAGGAAGCTTGCATTCTGTTTGGAATGAAATTGGTTCCGACGAAACGAATCGAATGAAAAAGGAGAATGCTAGAGCTGTATTTCGTGATGCCATTGCTAATGCTGGAACTGGACCTGCTCTGATGACCATCAAACGTTGGATCGAGAAGAAGGAGATCGAAGGATGCGAAGCTGCCGATGTTTTGGCGTCCATTCCTAAAACTGCGCGAACACCTACAGCCGAATACGTGGATGCTTTCTTTTCACTGGCAAGTAATCCAGAAGTACAAAAACAAACGTGTCTCAATTCGTCGGCTGTCTTATCCTTCGCTGAACTAGTACATCGCGCTCAAGTTTCTAACAGCAGCATTTACAATCACTATCCAGTTAACGTTTTCGGCCGTTTATCCTCTAGACGAAATGACGCAGTTCTAAGAAAATACATTCCGTTCTTCGCGGAAGAATTAAAGAAAGCTATCAAGGATGGAGATAGTCCAAGGATTCAGGTGTATATTCTCGCTTTAGGTTTAACAGGACATCCAAAGATACTGAACGTTTTAGAACCCTACCTTGAAGGCAAGGAACGAGTATCGACTTACCAACGTTTTCTGATGGTTATGTCTTTGAGAAAATTATGTGAGGTTAAACCTAGCCTGGCTCGTTCTGTCTTATACAAAATCTACCTCAATACCTGGGATGTTCATCAAATTCGTTGCGCTGCTGTCAACTTAATAATGAGAACTAATCCACCGTTAGATATGCTCACGCGGATGGCACAATTCACTAATACCGACTTCAGTGGACAGGTCAATTCAGCCGTTAAATCAGCGATCGAAAGTGCAGCTAACTTGAACTATCCCGAATGGGAAGAACTAACAAGGAATGCTCGCAAAGTGCTTCATTTAATGAATACGGAATCCGATAAGTATTATTACTCAGAGAGTCACTTCACAGAAATGGAAGAAAATGATCAGCTATCTTACAGAATGATGTTGAATTATATCGGAAGTGTAGATAACGTAATTCCATTGTCCACGCACTTTGCTTTACAACCCTCTTATAACGGCTTCCTCAGTCCTGTTTATGAATTAGATATGAGTATATCGAGCGTAAAAAGTCTATTAGAAATGTATTGGCATAAATCCGAAAAAGGAGATACTGAGGAGTCATTCGCAGAGAAAACTGCAAAAATGCTTCACATTGAATCAGACAATGTTGAGCAAGTCGAAGGAAATGTCTTCTTTAAGACGCCGTACCTTAACCGATACTTCTCTTTTGATAATCATACCATCGAAAGAATTTTACATGATATGGTGTCTCCAAGACATAGTCATCATGTTAACATGAACAAATTGTTGAGTTACGATATTACCTTGAGTTTTCCAACTGAAACTGGCTTACCTTTTGTTTACTCCTTACACGTACCTACAATCAAGAAATTCAGTGTTATAAGTAAACCAGATATGAAATCTAAATTTGATGTTCGTCTACTTACCTCTACTAAACATCAAGGAAGAGTTGGATTCATAACACCATTTGATCACCAAGCATTCCTATCGGGCATCGATAACAACATGCAAGTTTTCCTACCATGCAAACTAGATTTCCATTTAAATAATGAAAAATCCAGACTTGACGCAGCATTACAACCATTAAAACATAATAGCAAAACCAGGCTGGGACACTTTAGTGTGATACCTTACACCTCGCAATATGAAATAATGTCATTGCGCCCATTGCTCTTGGAGAAAAACACACATAGAATCCAAGAGAAAAAAACAACACATATTAGAATTCCACAAAATCCTAACAGCATTTTCTCCGTAGAAGTTGAAGCCGATAATCTTGCTGAAAAAATCCAGCAATGGTTAAGGAGTGAAAATAAGTGGGAAGATATGTTGTCCCCGTCATCATTGGCCTTAGGTACATACGAAAAAATCGATCTCTTTGTCAAGCCTGATCTACAAGAAAACGAAGCTGTTAAATTCACTGCCACGTTAGATACTAAAGAAATTAGATCGAACAATCTTGACACTAACGATGAATCCTGGAAATCCGGCAACAAAGTACTCAAGACAATGCACCAGGCGCTTGATAGCCCGGCCAGAAGGAAAGAATTTTTACAAGAGGTTGTTAAAGGAATAAATTCTGGAAAGGCTTACGTCATTGATGCAGGTCTGGAAGTACCTGGACTATGGAAGAGTAATCACGCATGTACCTTATGTTTAGCCAGTAGTAACGATGAAAATAAATTCCGAAGTATTTTCTACTGGTACACGAACATACCTAGTCAAGATATAACTTACCAAATGTGCGTTAATGGTCAGACAAGAAGCTCACCAACAACACCTTTCGATTATAAAAAAATACTTGACAGTAATCCAACGAACGAATTCAGCATTAACATTCAATCTGGAAGAACATGTACTGACAACTCGCTTGTCACTATCAAAGGACAGATCAAACAAAGTGAGGATTATAAGACGTACGTGCAAGAATCGAGGATAGTAAAAAGATGCGATGAAAATGTGAGAAATAGCGTGAAGGATTGCCAGAAAGCTGCAGAAATGGCTAAGAATCTAAACGAAATAGATATGACAATTACCAAACATAATTCTGCAGAAGAATCTGATACTGAATTAGAAAAAATATTCCATGGAACGAAGAAAATGTTAACAGGTTTAAACGTACGAGTTGTATCTGAAATTCAGGAACATTCTGATGTCAACGACAACGATATAAGGGTTCAGATAAAATTATCACCTAACATGACAAGCGCAGAAGGCATGGCATCTAAATCTGGACAGATTTTGACTTTCTCCGATATTCATATTGACATGGGAATTGATAATGACGATGAGATGAACGAAATTGAAAAAGGCATATTACATGGTGCCACGTGCACTCTTAGAAACAACGAAGCAGAAACTTTCGACGGTAAAGTCTATCCTCTGAAACTTGGTAAATGCGCACATGTCTTATTTACCACCTACCCAAGAAATGCACCGAATGAACCTAATAAGAGAATGAGCATTCCTGAAAATATGAAAGTGACCGTTATTGCCGAAGAAACGGAAAATAACAAAAAAGAACTTCAAATTTTGTTGGGTAATGACGAAATTCTGTTTAAATCATCTGGCACAGAAGTTTCAGCTTGGGTTAATGGACAAAAGGTGAAATGCTCACAGAAGGAAAGTTACCAACACATCAAGAATGATGAAACTCTCTTCGAAATATTTGAACTTCCTGGGCCTGCCATTAAATTGATATCAGATAAATATGATATTAAATTAGCCTACGATACAGACCATGTACAAATCGAGGTCCCTCACACATATCAACAATCCGTACGTGGTCTCTGTGGTGACTTTGATGGCCGATCCGAAAATGATTTCGTCACTCCAAAGAACTGTATGTTGCAGAAGCCAGAAGAATTTGCAGCCACTTATATATTGAAGGAACGATGCGAAGGACCGGCTTTGAATAATGCGAAAAAGGCAGAAAGGTCTAAATGCATAAGAAAAGTACTACGCTTCAGTGATGTGATAAGCGATGGAGAAGCTGGACGACCATATGTAAATTGGAAGCAATGGGGTTACCACAAGAAAGAAAATAAGAAACAATGCAATACTTATCGTACTCAAATTATCACTAAAGATGATAACATCTGTTTCACCATAAGGCCTGTACCAACATGTTCTAGCGGATGTAAATCTGTTGTAACAAAGCTAAAGGAATATCAACTCTATTGTTTACCAAAGAACGATTCAAGTTTAGGAATGAAAAAGAGAATTGAACAGGGAGCTAATCCTGATTTAAGTCAACGCACTCCTACTGATAATGCAATGATCAGTGTTCCCCTCGAATGTGTAGCTACCTGA

Protein[Download]

MRSRFILLLLGVAVSNLDNNIEHGWKVGEEYQYLVRSRTLTGLQTLSDQYAGILMKATLRIQCNSPDTLRAQLLKPQYAQIHKKLPDGWDSRISDQMLEHKHLPLSNEPFVIKLKHGVIRDLIVSKNVPTWEVNIIKSIISQFQADTQGENLKGNKNTQIPEDDNPFATFRVMEDCVSGKCEVLYDVVPLTEDVLQHRPHILPKPELRGNGEHIYITKTRNYDKCEQRMDYYFGISGNANWESDIRNNDKIMKKSSTSNMVISGNLKNFVIQTAVTTTEIIMKPRLVDDQESIVISKMNVTLVSVNKVSSPIPAPNNPESTGNLVYTYNDPFSKTVQRRLGRPSVSPNSMSNELDSSADSDEDLRLMREKYGKSDKMNVVSDEDKAFRQMKPTLHEAPKNPMLPLFIGNNGKAVVMSDKINSGKMVMTLVQEIASEMEDPNVMPDRETLEKFTIVSRLISSMSLEQINKAEGSLHSVWNEIGSDETNRMKKENARAVFRDAIANAGTGPALMTIKRWIEKKEIEGCEAADVLASIPKTARTPTAEYVDAFFSLASNPEVQKQTCLNSSAVLSFAELVHRAQVSNSSIYNHYPVNVFGRLSSRRNDAVLRKYIPFFAEELKKAIKDGDSPRIQVYILALGLTGHPKILNVLEPYLEGKERVSTYQRFLMVMSLRKLCEVKPSLARSVLYKIYLNTWDVHQIRCAAVNLIMRTNPPLDMLTRMAQFTNTDFSGQVNSAVKSAIESAANLNYPEWEELTRNARKVLHLMNTESDKYYYSESHFTEMEENDQLSYRMMLNYIGSVDNVIPLSTHFALQPSYNGFLSPVYELDMSISSVKSLLEMYWHKSEKGDTEESFAEKTAKMLHIESDNVEQVEGNVFFKTPYLNRYFSFDNHTIERILHDMVSPRHSHHVNMNKLLSYDITLSFPTETGLPFVYSLHVPTIKKFSVISKPDMKSKFDVRLLTSTKHQGRVGFITPFDHQAFLSGIDNNMQVFLPCKLDFHLNNEKSRLDAALQPLKHNSKTRLGHFSVIPYTSQYEIMSLRPLLLEKNTHRIQEKKTTHIRIPQNPNSIFSVEVEADNLAEKIQQWLRSENKWEDMLSPSSLALGTYEKIDLFVKPDLQENEAVKFTATLDTKEIRSNNLDTNDESWKSGNKVLKTMHQALDSPARRKEFLQEVVKGINSGKAYVIDAGLEVPGLWKSNHACTLCLASSNDENKFRSIFYWYTNIPSQDITYQMCVNGQTRSSPTTPFDYKKILDSNPTNEFSINIQSGRTCTDNSLVTIKGQIKQSEDYKTYVQESRIVKRCDENVRNSVKDCQKAAEMAKNLNEIDMTITKHNSAEESDTELEKIFHGTKKMLTGLNVRVVSEIQEHSDVNDNDIRVQIKLSPNMTSAEGMASKSGQILTFSDIHIDMGIDNDDEMNEIEKGILHGATCTLRNNEAETFDGKVYPLKLGKCAHVLFTTYPRNAPNEPNKRMSIPENMKVTVIAEETENNKKELQILLGNDEILFKSSGTEVSAWVNGQKVKCSQKESYQHIKNDETLFEIFELPGPAIKLISDKYDIKLAYDTDHVQIEVPHTYQQSVRGLCGDFDGRSENDFVTPKNCMLQKPEEFAATYILKERCEGPALNNAKKAERSKCIRKVLRFSDVISDGEAGRPYVNWKQWGYHKKENKKQCNTYRTQIITKDDNICFTIRPVPTCSSGCKSVVTKLKEYQLYCLPKNDSSLGMKKRIEQGANPDLSQRTPTDNAMISVPLECVAT

3D Structure

Alphafold Prediction

Publication

1.	Blank S., Seismann H., McIntyre M., Ollert M., Wolf S., Bantleon F.I., Spillner E.; "Vitellogenins Are New High Molecular Weight Components and Allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris Venom."; PLoS ONE 8:E62009-E62009(2013).

Venom Protein Card