iVenomDB

Basic info

Organism	Apis mellifera
Taxonomy	Insecta > Hymenoptera > Apidae > Apis > Apis mellifera
Protein Description	Venom carboxylesterase-6 precursor
Mass Weight	63636.41 Da
Isoelectric Point	9.33
Expression	Highly expressed in venom gland

Annotation

Pfam

PF00135

COesterase

Features

Feature key	Position	Length
Signal Peptide	1..21	21
Chain	22..557	536

Cross-Reference

NCBI Nucleotide	NM_001126244.1
NCBI Protein	NP_001119716.1
UniProt	B2D0J5

Sequence

CDS[Download]

ATGTACATGTTGAAACTATCGTACATTCTGCTATTTTTGGGATTCGTCAAGTTTTCGTGGCAAGACAAACAAGTTCCCAAAGTGAGCACATTTACAGGAAACATTCGTGGTTATTATAAGAAATCTCGATCTGATAGATTATACGAAGCTTATGAAGGTATTCCTTATGCGCAATCTCCAGTTGGTAAATTTAGATTCCAACCACCTCGACCAATAAAAAAATGGTCGAAAGATCTATCAGCCACGAAAAAAAGTTCCGTTTGTATGCAATATCTTATGACTTTTACGACACATGGAAACAGAGTGAAAGGTTCCGAAGATTGTTTGTATATAAATATTTACGTACCAGTTAGAAATAATAGAAAACCATTGTTACCGGTGATGTTTTGGATTCATGGAGGCGCCTTCCAGTTTGCCAGTGGGAACGAAGCAAACGAGACACTTTTTATGGATCGTAATATTGTGTTTGTTGCGATTAATTATCGTTTAGGACCATTTGGCTTCCTTAGTACCGGAGACATTGTAGTACCTGGAAATATGGGATTGAAAGATCAAAGTATGGCTTTACGTTGGGTGTTTAATAATATTAAAAGTTTCGGTGGTAATCCAAATAAAATAACAATTTTTGGAATGAGTGCGGGTGGTGCTAGTGTTCATTATCACTATTTATCACCTATGAGTGCCGGTCTTTTCAAAAGAGGAATATCGATAAGTGGTGTAGCATTCTGTCCTTGGGCACAGACGAAGCATGCTCCTGAAAAAGCTAAAAAATTGGGTGCTCTTATGAAATGTCGGACAGATAATACGAAAAAAATGATCGATTGTCTTCAAAGTCGACCTGCGCGAATTATAGCACAAGCTGTTGGCGATTTCATGTTTTGGTTGTATAATCCTTTTACTCCTTTCGGACCTGTTGTTGAGACATATGGATCCAATCCTTTTATTTCTAATTCTCCAATTAATATTATCAATAATGGTCAAGTTTATGATGTTCCTTGGATCTCTGGTGTAGTTAGCAAAGAAGGATTATATACTGCTGCAGAATTTGTTGACAATGCTAAACTGCTATGGCATTTGAACGATCATTGGGACGAAATTGCACCATATTTACTCGATTTCAATTATACTATTCCACTAGATCAGCATAGACAAGTGGCAAAAAAAATTAAAAATTATTATCTGAGATCAGGTCCGATTAATTATGACAAAGTGGAATCAATAATACAAATGATGAGTGATCGATTGTTCAACATCGATTTCGAGAAAGCTGTTAGATTACAAGCAAGAATTAACAAGAGTCCAGTATGGACATATTATTATAGTTACAGAGCTGAACATAGCGTTAGTGAAATTTTGAGCGGAGGTTCAACTACAGATTACGGAGTATGCCATGGCGATGACATATTCCTTACGCTTAATTCAATTATTTCAAACGTAACAAAACCACAAGATTTGGCTATGCAACAATTATTGATCAATTTTTATACATCATTTGCTATACAGGGTATTCCATATATAGACGAAGCTTCATGGCCATCGTTAAATCCTAATGATCCTGATTTTCGTTATCTGCATATAGTTAATTTTACAAACATAAAAATGGAAGTTAATAATAATTTTGCTAATAAAAGCTTTTGGAAAACGATTCCTTTTAACGAAAATAAGCTAAATTAG

Protein[Download]

MYMLKLSYILLFLGFVKFSWQDKQVPKVSTFTGNIRGYYKKSRSDRLYEAYEGIPYAQSPVGKFRFQPPRPIKKWSKDLSATKKSSVCMQYLMTFTTHGNRVKGSEDCLYINIYVPVRNNRKPLLPVMFWIHGGAFQFASGNEANETLFMDRNIVFVAINYRLGPFGFLSTGDIVVPGNMGLKDQSMALRWVFNNIKSFGGNPNKITIFGMSAGGASVHYHYLSPMSAGLFKRGISISGVAFCPWAQTKHAPEKAKKLGALMKCRTDNTKKMIDCLQSRPARIIAQAVGDFMFWLYNPFTPFGPVVETYGSNPFISNSPINIINNGQVYDVPWISGVVSKEGLYTAAEFVDNAKLLWHLNDHWDEIAPYLLDFNYTIPLDQHRQVAKKIKNYYLRSGPINYDKVESIIQMMSDRLFNIDFEKAVRLQARINKSPVWTYYYSYRAEHSVSEILSGGSTTDYGVCHGDDIFLTLNSIISNVTKPQDLAMQQLLINFYTSFAIQGIPYIDEASWPSLNPNDPDFRYLHIVNFTNIKMEVNNNFANKSFWKTIPFNENKLN

3D Structure

Alphafold Prediction

Publication

1.	Blank S., Seismann H., Bockisch B., Braren I., Bredehorst R., Grunwald T., Ollert M., Spillner E.; "Identification and recombinant expression of a novel IgE-reactive 70 kDa carboxylesterase from Apis mellifera venom."; Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
2.	"Insights into social insects from the genome of the honeybee Apis mellifera."; Nature 443:931-949(2006).

Venom Protein Card