iVenomDB

Basic info

Organism	Apis mellifera
Taxonomy	Insecta > Hymenoptera > Apidae > Apis > Apis mellifera
Protein Description	Major royal jelly protein 3 precursor
Mass Weight	61661.08 Da
Isoelectric Point	6.47
Expression	Highly expressed in venom gland

Annotation

Function

Secreted RNA-binding protein required to concentrate, stabilize and enhance environmental RNA bioavailability in the honeybee royal jelly. Acts as a RNA-aggregating protein: binds 18 nucleotides and longer single- and double-stranded RNA (ssRNA and dsRNA, respectively) in a non-specific manner. RNA- binding drives super-order assembly of oligomers into extracellular ribonucleoprotein granules that concentrate, protect and enhance RNA uptake granules, facilitating RNA transfer among bees.

Pfam

PF03022

MRJP

Features

Feature key	Position	Length
Signal Peptide	1..20	20
Chain	21..544	524

Cross-Reference

NCBI Nucleotide	NM_001011601.1
NCBI Protein	NP_001011601.1
UniProt	Q17060

Sequence

CDS[Download]

ATGACAAAGTGGTTGTTGCTGGTGGTGTGCCTTGGTATAGCTTGTCAAGATGTAACAAGCGCAGCTGTGAATCATCAAAGAAAATCTGCAAATAATTTGGCACATTCTATGAAAGTGATCTACGAATGGAAACACATTGATTTTGATTTCGGTAGCGATGAAAGAAGAGATGCTGCGATTAAATCTGGCGAATTTGATCACACAAAAAATTATCCTTTCGATGTGGACAGATGGCGTGATAAGACATTTGTCACCATAGAAAGGAACAATGGTGTACCTTCTTCTTTGAACGTGGTAACTAATAAAAAGGGCAAAGGTGGACCTCTTCTACGACCATATCCTGATTGGTCGTTTGCCAAATACGAAGATTGCTCTGGAATTGTGAGCGCTTTCAAAATTGCGGTCGACAAATTTGACAGATTATGGGTTCTGGACTCAGGTCTTGTCAATAATAATCAACCTATGTGCTCTCCAAAATTGTTAACCTTTGATCTGAAAACCTCAAAATTGGTTAAGCAAGTCGAGATACCACATAATATTGCCGTAAACGCCACCACAGGAATGGGAGAATTAGTTTCACTAGCTGTTCAAGCTATAGATCGTACGAATACTATGGTGTACATAGCAGACGAAAAAGGCGAAGGTTTAATCATGTATCAAAACTCCGACGATTCCTTCCATCGATTGACTTCCAATACTTTCGATTACGATCCCAGATATACCAAATTGACAGTCGCTGGAGAAAGTTTCACAGTGAAAAATGGAATTTATGGAATTGCACTTAGTCCCGTGACGAACAATCTTTATTACAGCCCTCTTCTTTCTCACGGTTTGTATTATGTTGATACGGAACAATTCAGCAATCCACAATATGAAGAAAATAACGTGCAATATGAAGGATCTCAAGATATTTTGAACACTCAATCATTCGGTAAAGTAGTATCGAAAAATGGCGTCCTTTTCTTGGGACTCGTGGGTAATTCAGGTATTGCCTGCGTGAATGAACATCAAGTACTTCAGAGAGAAAGTTTTGATGTTGTCGCTCAGAATGAAGAGACACTTCAAATGATCGTTAGTATGAAAATCATGGAAAATCTTCCACAATCCGGCAGAATTAATGATCCTGAAGGCAATGAATATATGTTGGCTTTGAGTAACAGAATGCAAAAAATAATAAACAATGATTTTAATTTCAACGACGTAAATTTCCGAATTTTGGGTGCGAATGTAGATGACTTAATGAGAAACACTCGTTGCGGAAGATATCACAATCAGAATGCTGGCAATCAGAATGCTGACAATCAGAATGCTGACAATCAGAATGCTAACAATCAGAATGCTGATAATCAGAATGCTAACAAACAAAATGGTAATAGACAAAATGATAACAGACAGAATGATAACAAGCAAAATGGTAACAGACAGAATGATAACAAGCAAAATGGTAACAGACAGAATGATAACAAGCAAAATGGTAACAGACAAAATGGTAACAAACAGAATGATAACAAGCAAAATGGTAACAGACAGAATGATAACAAGAGGAATGGTAACAGGCAAAATGATAATCAAAATAATCAGAATGATAATAATCGAAATGATAATCAAGTTCATCATTCTTCAAAATTACATTAA

Protein[Download]

MTKWLLLVVCLGIACQDVTSAAVNHQRKSANNLAHSMKVIYEWKHIDFDFGSDERRDAAIKSGEFDHTKNYPFDVDRWRDKTFVTIERNNGVPSSLNVVTNKKGKGGPLLRPYPDWSFAKYEDCSGIVSAFKIAVDKFDRLWVLDSGLVNNNQPMCSPKLLTFDLKTSKLVKQVEIPHNIAVNATTGMGELVSLAVQAIDRTNTMVYIADEKGEGLIMYQNSDDSFHRLTSNTFDYDPRYTKLTVAGESFTVKNGIYGIALSPVTNNLYYSPLLSHGLYYVDTEQFSNPQYEENNVQYEGSQDILNTQSFGKVVSKNGVLFLGLVGNSGIACVNEHQVLQRESFDVVAQNEETLQMIVSMKIMENLPQSGRINDPEGNEYMLALSNRMQKIINNDFNFNDVNFRILGANVDDLMRNTRCGRYHNQNAGNQNADNQNADNQNANNQNADNQNANKQNGNRQNDNRQNDNKQNGNRQNDNKQNGNRQNDNKQNGNRQNGNKQNDNKQNGNRQNDNKRNGNRQNDNQNNQNDNNRNDNQVHHSSKLH

3D Structure

Not available now!

Publication

1.	Klaudiny J., Hanes J., Kulifajova J., Albert S., Simuth J.; "Molecular cloning of two cDNAs from the head of the nurse honey bee (Apis mellifera L.) for coding related proteins of royal jelly."; J. Apic. Res. 33:105-111(1994).
2.	Albert S., Klaudiny J., Simuth J.; "Newly discovered features of the updated sequence of royal jelly protein RJP571; longer repetitive region on C-terminus and homology to Drosophila melanogaster yellow protein."; J. Apic. Res. 35:63-68(1996).
3.	Schmitzova J., Klaudiny J., Albert S., Schroeder W., Schreckengost W., Hanes J., Judova J., Simuth J.; "A family of major royal jelly proteins of the honeybee Apis mellifera L."; Cell. Mol. Life Sci. 54:1020-1030(1998).
4.	Ohashi K., Natori S., Kubo T.; "Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L."; Eur. J. Biochem. 249:797-802(1997).
5.	Maori E., Navarro I.C., Boncristiani H., Seilly D.J., Rudolph K.L.M., Sapetschnig A., Lin C.C., Ladbury J.E., Evans J.D., Heeney J.L., Miska E.A.; "A secreted RNA binding protein forms RNA-stabilizing granules in the honeybee royal jelly."; Mol. Cell 74:598-608(2019).

Venom Protein Card