Venom Protein Card
Accession: Pre05174 Mast cell degranulating peptide [Apis mellifera]
Basic info
| Organism | Apis mellifera |
| Taxonomy | Insecta > Hymenoptera > Apidae > Apis > Apis mellifera |
| Protein Description | Mast cell degranulating peptide |
| Mass Weight | 5781.12 Da |
| Isoelectric Point | 9.87 |
| Expression | Highly expressed in venom gland |
Annotation
| Function | Potent anti-inflammatory agent. At low concentrations, mediates the degranulation of mast cells thus evoking an inflammatory response. Also acts as a neurotoxin capable of blocking a class of voltage-gated potassium channels. | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1..27 | 27 |
| Peptide | 28..49 | 22 |
Sequence
Publication
| 1. |
Gmachl M., Kreil G.; "The precursors of the bee venom constituents apamin and MCD peptide are encoded by two genes in tandem which share the same 3'-exon."; J. Biol. Chem. 270:12704-12708(1995). |
| 2. |
Haux P.; "Amino acid sequence of MCD-peptide, a specific mast cell-degranulating peptide from bee venom."; Hoppe-Seyler's Z. Physiol. Chem. 350:536-546(1969). |
| 3. |
Doonan S., Garman A.J., Hanson J.M., Loudon A.G., Vernon C.A.; "Identification by mass spectrometry of N(epsilon)-formyl-lysine."; J. Chem. Soc. Perkin Trans. I 12:1157-1160(1978). |
| 4. |
Billingham M.E.J., Morley J., Hanson J.M., Shipolini R.A., Vernon C.A.; "An anti-inflammatory peptide from bee venom."; Nature 245:163-164(1973). |
| 5. |
Ziai M.R., Russek S., Wang H.-C., Beer B., Blume A.J.; "Mast cell degranulating peptide: a multi-functional neurotoxin."; J. Pharm. Pharmacol. 42:457-461(1990). |