iVenomDB

Venom Protein Card

Accession: Pre05181 Allergen Api m 6.03 / Api m 6.04 precursor [Apis mellifera]

Basic info

Organism	Apis mellifera
Taxonomy	Insecta > Hymenoptera > Apidae > Apis > Apis mellifera
Protein Description	Allergen Api m 6.03 / Api m 6.04 precursor
Mass Weight	9818.84 Da
Isoelectric Point	9.83
Expression	Highly expressed in venom gland

Annotation

Function

May act as a protease inhibitor.

Pfam

PF01826

TIL

Features

Feature key	Position	Length
Signal Peptide	1..21	21
Chain	22..92	71
Chain	26..92	67

Cross-Reference

NCBI Nucleotide	NM_001040270.1
NCBI Protein	NP_001035360.1
UniProt	P83563

Sequence

CDS[Download]

ATGTCTCGTCTGGTTCTTGCCTCCTTCCTTCTTTTGGCAATTTTCTCCATGCTTGTTGGAGGATTTGGAGGATTTGGAGGATTTGGAGGACTTGGAGGACGTGGTAAATGTCCAAGCAATGAGATCTTCAGTAGATGCGATGGACGGTGCCAACGTTTTTGCCCCAATGTTGTTCCTAAACCTTTATGCATCAAGATATGTGCACCAGGATGTGTATGTAGACTTGGTTATTTAAGGAATAAAAAGAAGGTATGCGTTCCGCGATCTAAATGCGGATGA

Protein[Download]

MSRLVLASFLLLAIFSMLVGGFGGFGGFGGLGGRGKCPSNEIFSRCDGRCQRFCPNVVPKPLCIKICAPGCVCRLGYLRNKKKVCVPRSKCG

3D Structure

Alphafold Prediction

Publication

1.	Peiren N., de Graaf D.C., Evans J.D., Jacobs F.J.; "Genomic and transcriptional analysis of protein heterogeneity of the honeybee venom allergen Api m 6."; Insect Mol. Biol. 15:577-581(2006).
2.	Wu J.L., Liu J.H., Yuan Y.N., Qiao L.Y., Liu W.Z.; Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
3.	Kettner A., Hughes G.J., Frutiger S., Astori M., Roggero M., Spertini F., Corradin G.; "Api m 6: a new bee venom allergen."; J. Allergy Clin. Immunol. 107:914-920(2001).
4.	Michel Y., McIntyre M., Ginglinger H., Ollert M., Cifuentes L., Blank S., Spillner E.; "The putative serine protease inhibitor Api m 6 from Apis mellifera venom: recombinant and structural evaluation."; J. Investig. Allergol. Clin. Immunol. 22:476-484(2012).
5.	Submitted (JAN-2017) to UniProtKB.