Venom Protein Card
Accession: Pre05207 Secapin preproprotein [Apis mellifera]
Basic info
| Organism | Apis mellifera |
| Taxonomy | Insecta > Hymenoptera > Apidae > Apis > Apis mellifera |
| Protein Description | Secapin preproprotein |
| Mass Weight | 8679.21 Da |
| Isoelectric Point | 9.51 |
| Expression | Highly expressed in venom gland |
Annotation
| Function | Serine protease inhibitor which exhibits antifibrinolytic, antielastolytic and antimicrobial activities (By similarity). Displays antimicrobial activity against bacteria and fungi (By similarity). Likely functions in the innate immune response to microbial infection and possibly in the venom, as an antifibrinolytic agent (By similarity). Not toxic to mice but does induce slight sedation at higher doses (from 40 mg/kg). At a dose of 80 mg/kg, sedation occurs 15 minutes after injection and is accompanied by piloerection and hypothermia. | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1..32 | 32 |
| Propeptide | 33..52 | 20 |
| Peptide | 53..77 | 25 |
Sequence
Publication
| 1. |
Vlasak R., Kreil G.; "Nucleotide sequence of cloned cDNAs coding for preprosecapin, a major product of queen-bee venom glands."; Eur. J. Biochem. 145:279-282(1984). |
| 2. |
Kreil G.; Submitted (JUN-1986) to the EMBL/GenBank/DDBJ databases. |
| 3. |
Zhang S.F., Shi W.J., Zhang C.X., Cheng J.A.; "Cloning and sequencing of cDNA encoding preprosecapin from the venom of Apis cerana cerana and Apis mellifera."; Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. |
| 4. |
Gauldie J., Hanson J.M., Shipolini R.A., Vernon C.A.; "The structures of some peptides from bee venom."; Eur. J. Biochem. 83:405-410(1978). |
| 5. |
Gauldie J., Hanson J.M., Rumjanek F.D., Shipolini R.A., Vernon C.A.; "The peptide components of bee venom."; Eur. J. Biochem. 61:369-376(1976). |